Insulin Resistance: The Metabolic Syndrome X / Edition 1

by Gerald M. Reaven, Ami Laws

Overview

Gerald Reaven, the discoverer of Syndrome X, and a panel of world-class investigators thoughtfully summarize our current understanding of how insulin resistance and its compensating hyperinsulinemia play a major role in the pathogenesis and clinical course of high blood pressure and cardiovascular disease-the so-called diseases of Western civilization. These distinguished authorities detail, for the first time, the pathophysiological consequences and the clinical syndromes, excluding Type 2 diabetes, related to insulin resistance. They also examine the genetic and lifestyle factors that contribute to the wide differences in insulin action that exist in the population at large. Timely and authoritative, Insulin Resistance: The Metabolic Syndrome X illuminates the full importance of insulin resistance as a major cause of hypertension, heart disease, and polycystic ovary syndrome.

Product Details

ISBN-13:	9781617370861
Publisher:	Springer-Verlag New York, LLC
Publication date:	11/09/2010
Series:	Contemporary Endocrinology , #12
Edition description:	Softcover reprint of the original 1st ed. 1999
Pages:	374
Product dimensions:	7.01(w) x 10.00(h) x 0.03(d)

About the Author

Reaven, Gerald M., MD (Stanford Univ); Laws, Ami, MD (Stanford Univ)

Table of Contents

I Genetic and Environmental Factors Affecting Insulin Action.- 1 Genetics of Insulin Resistance.- 2 Ethnic Variation in Insulin Resistance and Risk of Type 2 Diabetes.- 3 Fetal Effects on Insulin Resistance and Glucose Tolerance.- 4 Obesity and Insulin Resistance: Epidemiologic, Metabolic, and Molecular Aspects.- 5 The Role of Body Fat Distribution in Insulin Resistance.- 6 Physical Activity and Insulin Resistance in Man.- 7 Insulin Resistance in Smokers and Other Long-Term Users of Nicotine.- II Pathophysiology of Insulin Resistance.- 8 Insulin Resistance and Inhibitors of Insulin Receptor Tyrosine Kinase.- 9 NMR Studies on the Mechanism of Insulin Resistance.- 10 Skeletal Muscle Insulin Resistance in Humans: Cellular Mechanisms.- 11 The Role of the Liver in Insulin Action and Resistance.- 12 The Pathophysiological Consequences of Adipose Tissue Insulin Resistance.- 13 Insulin Action and Endothelial Function.- III Clinical Syndromes Associated with Insulin Resistance.- 14 Insulin Resistance and Dyslipidemia: Implications for Coronary Heart Disease Risk.- 15 Insulin Resistance and Blood Pressure.- 16 Microalbuminuria and Insulin Resistance.- 17 PAI-1, Obesity, and Insulin Resistance.- 18 Insulin Resistance and Cardiovascular Disease.- 19 Insulin Resistance Effects on Sex Hormones and Ovulation in the Polycystic Ovary Syndrome.

Editorial Reviews

"Gerald Reaven was among the pioneers in this burgeoning field. He identified insulin resistance as a risk factor for and pathophysiologic trigger of disorders as apparently unconnected as hypertension, hyperlipidemia, and polycystic ovary disease. Reaven and Laws have now brought together the diverse elements of this field in a book that will be of broad interest to the medical community. . .This book is an excellent and useful compendium of information about this rapidly moving field. It will be an essential addition to the libraries of those interested in any of the disorders linked to this prevalent metabolic state."-New England Journal of Medicine

"the authors present a critical analysis and overview of the latest research in this fast changing field. . .an authoritative work on the current state of the knowledge on insulin resistance, and its major role in the pathogenesis and development of accelerated atherosclerosis and premature cardiovascular disease-the bane of modern civilization. It is of value to all basic and clinical researchers in this field."-Quarterly Review of Biology

" This is an excellent book that will be particularly informative for those readers who are interested in understanding the mechanisms underlying the development of insulin resistance and the clinical and public health consequences of the metabolic syndrome. It should find a place on the bookshelves not only of scientists actively involved in this area of research but also of practicing physicians and medical students." —-Nutrition, Metabolism and Cardiovascular Diseases

" Each section stands out as an in-depth review of the literature on each topic. Subject matter overlaps little among the chapters, and each chapter can be read independently." —-Annals of Internal Medicine

"Who better to edit and contribute to a book on insulin resistance than Gerald Reaven, ...As a major contributor to the notion of a 'metabolic syndrome', Reaven hashelped develop our ideas in this area for many years, bringing a pattern of thinking to an extremely complex area....the breadth of the book and the universally clear presentation and focus suggest that there should be something for everyone. Laws contributes an excellent chapter on insulin resistance, dyslipidemia and CVD,...remarkably consistent across the chapters, they were well focused, logically presented and comprehensive....The insulin resistance framework forms a pattern that has proven remarkably important in helping develop research strategies and this book helped me understand the many and varied facets of this pattern." -Elsevier Science

From the Publisher

3 Stars from Doody

This book is an excellent and useful compendium of information about this rapidly moving field. It will be an essential addition to the libraries of those interested in any of the disorders linked to this prevalent metabolic state.

New England Journal of Medicine

This volume in the Contemporary Endocrinology Series is a multiauthored text designed to summarize the current understanding of the importance of insulin resistance, particularly as it relates to non-diabetic states. The purpose is to provide the reader with information about the importance of insulin resistance in non-diabetic states. It is appropriate for any clinician or investigator who encounters adult patients. The spectrum of metabolic disturbances associated with insulin resistance is broad, making this book appealing to generalists as well as subspecialists. This book is structured in three parts. Part one covers genetic and environmental factors affecting insulin action; part two covers the pathophysiology of insulin resistance; and part three deals with clinical syndromes associated with insulin resistance. This book is particularly useful in that it bridges the gaps in what is known about the fundamental elements of insulin action and the clinical sequelae. For example, the complexities of the relationship between obesity and insulin resistance are clearly handled. This is an excellent and welcome addition to the field: concise, clearly written, and current.

David A. Ehrmann

Reaven, who discovered Syndrome X, assembles summaries of the current understanding of how insulin resistance and its compensating hyperinsulinemia play a major role in the pathogenesis and clinical course of high blood pressure, cardiovascular disease, and polycystic ovary syndrome. They detail the pathophysiological consequences and the clinical syndromes besides Type 2 diabetes that are related to insulin resistance, and explore the genetic and lifestyle factors that contribute to the wide differences in insulin action that exist in the population at large. Of interest to both researchers and clinicians. Annotation c. by Book News, Inc., Portland, Or.

Booknews

Reviewer: David A. Ehrmann, MD (University of Chicago Medical Center)
Description: This volume in the Contemporary Endocrinology Series is a multiauthored text designed to summarize the current understanding of the importance of insulin resistance, particularly as it relates to non-diabetic states.
Purpose: The purpose is to provide the reader with information about the importance of insulin resistance in non-diabetic states.
Audience: It is appropriate for any clinician or investigator who encounters adult patients. The spectrum of metabolic disturbances associated with insulin resistance is broad, making this book appealing to generalists as well as subspecialists.
Features: This book is structured in three parts. Part one covers genetic and environmental factors affecting insulin action; part two covers the pathophysiology of insulin resistance; and part three deals with clinical syndromes associated with insulin resistance. This book is particularly useful in that it bridges the gaps in what is known about the fundamental elements of insulin action and the clinical sequelae. For example, the complexities of the relationship between obesity and insulin resistance are clearly handled.
Assessment: This is an excellent and welcome addition to the field: concise, clearly written, and current.

Doody's Review Service