Advances in Cancer Research

by George F. Vande Woude, George Klein

Overview

Advances in Cancer Research provides invaluable information on the exciting and fastmoving field of cancer research. Here, once again, outstanding and original reviews are presented and include:

Insights into the Evolution of Lymphomas induced by Epstein-Barr Virus

Recent Advances in the Research of Hepatitis B Virus-Related Hepatocellular Carcinoma: Epidemiologic and Molecular Biological Aspects

The ATM-Chk2 and ATR-Chk1 Pathways in DNA Damage Signaling and Cancer

microRNAs in Cancer: From Bench to Bedside

Product Details

ISBN-13:	9780123808882
Publisher:	Elsevier Science
Publication date:	11/12/2010
Series:	Advances in Cancer Research , #108
Pages:	170
Product dimensions:	6.00(w) x 9.00(h) x (d)

About the Author

Vande Woude, George F.; Klein, George

Table of Contents

Insights into the Evolution of Lymphomas Induced by Epstein-Barr Virus David Vereide Bill Sugden

I EBV and its Extensive Presence in Lymphomas 2

II Tumor Cells Differ in Their Dependence on EBV 6

III A Model for EBV-Induced Lymphomagenesis 9

IV Conclusion 14

References 15

Recent Advances in the Research of Hepatitis B Virus-Related Hepatocellular Carcinoma: Epidemiologic and Molecular Biological Aspects Jia-Horng Kao Pei-Jer Chen Ding-Shinn Chen

I Introduction 22

II Factors Associated with HCC Development in Patients with Chronic HBV Infection 26

III Viral Factors in HBV-Related HCC 27

IV Nonviral Factors in HBV-Related HCC 44

V Primary Prevention of HBV-Related HCC 45

VI Molecular Carcinogenesis of HBV-Related HCC 46

VII Genetic Variations and HCC: Virus and Host Perspectives 50

VIII Conclusions 60

References 61

The ATM-Chk2 and ATR-Chk1 Pathways in DNA Damage Signaling and Cancer Joanne Smith Lye Mun Tho Naihan Xu David A. Gillespie

I Introduction 74

II Activation of the ATM-Chk2 and ATR-Chk1 DNA Pathways 75

III Checkpoint Functions of the ATM-Chk2 and ATR-Chk1 Pathways 79

IV The Three Rs of Damage Signaling: Resection, Recombination, and Repair 84

V ATM-Chk2 and ATR-Chk1 Pathway Alterations in Cancer 87

VI Exploiting Homologous Recombinational Repair (HRR) Defects for Cancer Therapy 92

VII DNA Damage Signaling as a Barrier to Tumorigenesis 95

VIII Checkpoint Suppression as a Therapeutic Principle 97

IX Future Perspectives 102

References 104

microRNAs in Cancer: From Bench to Bedside Maria Angelica Cortez Cristina Ivan Peng Zhou Xue Wu Mircea Ivan George Adrian Calin

I Introduction 114

II Alterations of miRNA Expression in Cancer 115

III Causes of miRNA Expression Variations 117

IV Pathways Involving miRNA Alterations 126

V Clinical Applications 136

VI Concluding Remarks 143

References 144

Index 159

What People are Saying About This

From the Publisher

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research.

Editorial Reviews

2 Stars from Doody

The review topics in this volume of Advances in Cancer Research series are well-chosen, timely, and in areas of high interest. They are also broadly directed and cover genes of known interest in cancer (c-src, myb) and emerging viral agents (KSHV/HHV8). The reviews provide new insights into known areas of interest, such as the ability of tumor cells to escape restraints on cell attachment, synergy of carcinogens with particular focus on those in cigarette smoke and those in the environment, responses of the immune system to a defined tumor type, and multistep progression in colon carcinogenesis as related to tumor cell phenotypes. This volume does not include a preface, but the series as a whole has always had the goal of providing cancer researchers with up-to-date reviews of the literature in active areas of research and interest. In this regard, the topics have been carefully selected and should have high interest for those in the field. Careful reviews on specific topics have been invaluable to investigators moving in new directions, as well as to those teaching at graduate and postgraduate levels. The authors of the individual reviews in this volume are recognized contributors to their specific fields, and their credibility assures the reader of a fair and thorough overview of the specific field. Other than cancer biology, there is no particular connection between the topics of the reviews in this volume, but that is not expected in a series like this. With the heterogeneity in topics and contributors, there is variability in style and presentation, also not unexpected. All the reviews have in common a thorough overview of the current literature, through at least 1997 and into1998. Certain reviews have the additional element of presenting a novel synthesis of concepts in the field. Notable here is the review by Breivik and Gaudernack, which relates possible mechanisms of DNA damage to colon carcinogenesis and the emergence of tumors with MIN and CIN phenotypes in specific portions of this complex organ. Similarly, although primarily an epidemiologic presentation, the goal of the review on possible synergy between carcinogens in cigarette smoke and others in the environment is increased public awareness. This is extremely important, although the audience reached by this particular volume may be those who are already conscious of the need for public education. Reviews on the known oncogenes myb and c-src join a vast literature but do provide particularly up-to-date insights on the biochemistry of these molecules and, in the case of c-src, of the importance of c-src in human cancer with potential therapeutic implications. This is a worthy addition to a series that has a long tradition of excellence in the field of cancer biology. As a teacher of cancer biology, I draw heavily on reviews such as these when teaching outside my own area of expertise and I am likely to use several of these reviews in teaching graduate students over the next year or two.

Kathleen Rundell

This classic and essential series presents critical overviews on select aspects of both cancer research and the basic underlying sciences.

American Scientist

Excellent, highly informative, in-depth reviews...expertly written, up-to-date, and well-referenced.

of Medicinal Journal Chemistry

This volume 70 in the series Advances in Cancer Research reviews early stage advances in cancer research, describes methods for analyzing the phenotype of cancer cells, and then focuses discussion on several important topics in cancer research, including cancer immunotherapy, genetics of the nevoid basal cell carcinoma syndrome, and roles of TGF-beta, c-myc, and the ret proto-oncogene. This book is intended to provide critical overviews on selected topics in both basic and clinical cancer research. This worthy purpose is superbly achieved. This book provides an excellent reference for students, residents, professors, medical doctors, and other biomedical professionals to quickly grasp some history and current status of cancer research and to obtain key references for further reading in the areas covered in the text. This book features a nice cover, informative table of contents, and effective index. Subtitles in the text are concise and very helpful for readers to get the overall picture. Technical jargon is defined and explained in broad terms. The illustrations are clear and of high quality. It would be even better if some of the illustrations were color. This is an excellent volume in this series. This book is highly valuable for individuals or organizations with interests in cancer research and/or cancer management. This informative, well-organized, up-to-date, and well-referenced volume is handsomely presented. Reading this book is truly enjoyable. I strongly recommend this text for students, biomedical researchers, and healthcare professionals.

Zhou Wang

Volume 61 contains seven papers addressing cancer prevention research trials; molecular genetic changes in human breast cancer; molecular approaches to cancer therapy; regulation and mechanism of mammalian gene amplification; unraveling the function of the retinoblastoma gene; tumor protection by inhibitors of protein phosphatases 1 and 2A--the okadaic acid class of compounds; and oncogenic basis of radiation resistance. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews

Reviewer: Zhou Wang, PhD (Northwestern University Feinberg School of Medicine)
Description: This volume 70 in the series Advances in Cancer Research reviews early stage advances in cancer research, describes methods for analyzing the phenotype of cancer cells, and then focuses discussion on several important topics in cancer research, including cancer immunotherapy, genetics of the nevoid basal cell carcinoma syndrome, and roles of TGF-beta, c-myc, and the ret proto-oncogene.
Purpose: This book is intended to provide critical overviews on selected topics in both basic and clinical cancer research. This worthy purpose is superbly achieved.
Audience: This book provides an excellent reference for students, residents, professors, medical doctors, and other biomedical professionals to quickly grasp some history and current status of cancer research and to obtain key references for further reading in the areas covered in the text.
Features: This book features a nice cover, informative table of contents, and effective index. Subtitles in the text are concise and very helpful for readers to get the overall picture. Technical jargon is defined and explained in broad terms. The illustrations are clear and of high quality. It would be even better if some of the illustrations were color.
Assessment: This is an excellent volume in this series. This book is highly valuable for individuals or organizations with interests in cancer research and/or cancer management. This informative, well-organized, up-to-date, and well-referenced volume is handsomely presented. Reading this book is truly enjoyable. I strongly recommend this text for students, biomedical researchers, and healthcare professionals.

Doody's Review Service

Praise for the Serial "This classic and essential series presents critical overviews on select aspects of both cancer research and the basic underlying sciences." —American Scientist "Excellent, highly informative, in-depth reviews…expertly written, up-to-date, and well-referenced." —Journal of Medicinal Chemistry "This is a series that has a long tradition of excellence in the field of cancer biology." —Doody’s Publishing Reviews

From the Publisher