The Metabotropic Glutamate Receptors / Edition 1

by P. Jeffrey Conn, Jitendra Patel

Overview

The Metabotropic Glutamate Receptors offers state-of-the-art summaries and reviews of virtually everything known today about metabotropic glutamate receptors (mGluRs), including their molecular biology, pharmacology, anatomical distribution, and physiological and pathological roles. Illuminating the overall role played by this crucial class of receptors in brain function, the book also pinpoints those areas in which there is the greatest continuing need for focused research.

Because mGluRs have the potential for participating in virtually all known functions of the central nervous system (CNS), the opportunity now exists to develop pharmacological agents that can potentially alter many brain disease processes by selective interaction with precise CNS functions. With its critical and insightful reviews, The Metabotropic Glutamate Receptors will immediately become your essential key to the development of novel treatment strategies for the widest variety of neurological disorders.

Product Details

ISBN-13:	9781617370069
Publisher:	Springer-Verlag New York, LLC
Publication date:	11/09/2010
Series:	The Receptors
Edition description:	Softcover reprint of hardcover 1st ed. 1995
Pages:	277
Product dimensions:	5.98(w) x 9.02(h) x 0.35(d)

About the Author

Conn, P. Jeffrey (Emory Univ); Patel, Jitendra (Zeneca Pharmaceuticals)

The contributors represent the specialties of pharmacology, toxicology, pathology, and biochemistry. Most come from the U.S., Italy, Denmark, and Switzerland. Institutions prominently represented include Univ of Catania, Emory Univ, and Univ of Chicago.

Table of Contents

1 • Molecular Cloning, Expression, and Characterization of Metabotropic Glutamate Receptor Subtypes.- 2 • Pharmacological Properties of Metabotropic Glutamate Receptors.- 3 • Second-Messenger Systems Coupled to Metabotropic Glutamate Receptors.- 4 • Anatomical Distribution of Metabotropic Glutamate Receptors in Mammalian Brain.- 5 • Modulation of Ionic Currents by Metabotropic Glutamate Receptors in the CNS.- 6 • Acute Regulation of Synaptic Transmission by Metabotropic Glutamate Receptors.- 7 • Long-Lasting Modulation of Synaptic Transmission by Metabotropic Glutamate Receptors.- 8 • Regulation of Neuronal Circuits and Animal Behavior by Metabotropic Glutamate Receptors.- 9 • Roles of Metabotropic Glutamate Receptors in Neuronal Degeneration.- 10 • Plasticity of Metabotropic Glutamate Receptors in Physiological and Pathological Conditions.

Editorial Reviews

A comprehensive review of the current knowledge about metabotropic glutamate receptors, including their molecular biology, pharmacology, anatomical distribution, and physiological and pathological roles. In addition to illuminating the overall role played by this class of receptors in brain function, the volume also pinpoints the areas in which there is the greatest continuing need for focused research. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews

...gives a state-of-the-art in the field (and) points out the needs of future research.-Trends in Pharmacological Sciences Review

This book is an excellent review of the molecular biology, pharmacology, anatomical distribution, and physiological and pathological roles of metabotrophic glutamate receptors. It provides a substantial support for the knowledge of metabotrophic glutamate receptor role in brain function and pathology. The editors have done an excellent job in choosing the contributing authors; each one is a major figure in the specific area he or she is presenting...recommended...-Neurological Research

...not only gives a state-of-the-art in the field but also points out the needs of future research thereby becomes of interest to scientists working both with metabotropic glutamate receptors and with receptors in general.-FEBS Letters

From the Publisher