Fatigue: Neural and Muscular Mechanisms / Edition 1

by Patricia A. Pierce, Roger M. Enoka, Simon C. Gandevia, Alan J. McComas, Douglas G. Stuart

Overview

This volume describes the current state of our knowledge on the neurobiology of muscle fatigue, with consideration also given to selected integrative cardiorespiratory mechanisms. Our charge to the authors of the various chapters was twofold: to provide a systematic review of the topic that could serve as a balanced reference text for practicing health-care professionals, teaching faculty, and pre-and postdoctoral trainees in the biomedi­ cal sciences; and to stimulate further experimental and theoretical work on neurobiology. Key issues are addressed in nine interrelated areas: fatigue of single muscle fibers, fatigue at the neuromuscular junction, fatigue of single motor units, metabolic fatigue studied with nuclear magnetic resonance, fatigue of the segmental motor system, fatigue involving suprasegmental mechanisms, the task dependency of fatigue mechanisms, integrative (largely cardiorespiratory) systems issues, and fatigue of adapted systems (due to aging, under-and overuse, and pathophysiology). The product is a volume that provides compre­ of processes that operate from the forebrain to the contractile proteins.

Product Details

ISBN-13:	9780306451393
Publisher:	Springer US
Publication date:	11/30/1995
Series:	Advances in Experimental Medicine and Biology , #384
Edition description:	1995
Pages:	542
Product dimensions:	7.01(w) x 10.00(h) x 0.39(d)

About the Author

Gandevia, Simon C. (Prince of Wales Medical Research Institute, Sydney); Enoka, Roger M. (Cleveland Clinic Foundation); McComas, Alan J. (McMaster Univ); Stuart, Douglas G. (Univ of Arizona); Thomas, Christine K. (Univ of Miami)

The contributors participated in a symposium on Neural and Neuromuscular Aspects of Muscular Fatigue held in November 1994 in Florida.

Table of Contents

Looking Back.- The Scientific Contributions of Brenda Bigland-Ritchie.- Section I: Fatigue of Single Muscle Fibers.- 1. Myofibrillar Fatigue versus Failure of Activation.- 2. Mechanisms of Excitation-Contraction Coupling Relevant to Skeletal Muscle Fatigue.- 3. The Role of Intracellular Acidosis in Muscle Fatigue.- 4. Role of Interstitial Potassium.- Section II: Fatigue at the Neuromuscular Junction.- 5. Fatigue at the Neuromuscular Junction: Branch Point vs. Presynaptic vs. Postsynaptic Mechanisms.- 6. The Role of the Sarcolemma Action Potential in Fatigue.- 7. Single Fiber Electromyography in Studies of Neuromuscular Function.- Section III: Fatigue of Single Motor Units.- 8. Intrinsic Properties of Motoneurons: Implications for Muscle Fatigue.- 9. Neuromuscular Frequency Coding and Fatigue.- 10. Human Motor Units Studied by Spike-Triggered Averaging and Intraneural Motor Axon Stimulation.- 11. Human Motor Units Studied by Intramuscular Microstimulation.- Section IV: Fatigue Studied with NMR Techniques.- 12. Bioenergetics and Muscle Cell Types.- 13. Metabolic Correlates of Fatigue from Different Types of Exercise in Man.- 14. Mechanisms of Human Muscle Fatigue: Quantitating the Contribution of Metabolic Factors and Activation Impairment.- 15. Emerging Opportunities with NMR.- Section V: The Case for Segmental Motor Mechanisms.- 16. Variable-Frequency Stimulation Patterns for the Optimization of Force during Muscle Fatigue: Muscle Wisdom and the Catch-like Property.- 17. Overview: Potential Role of Segmental Motor Circuitry in Muscle Fatigue.- 18. The Fusimotor System: Its Role in Fatigue.- 19. Role of Muscle Afferents in the Inhibition of Motoneurons during Fatigue.- Section VI: The Case for Central Fatigue.- 20. Central Fatigue: Critical Issues, Quantification and Practical Implications.- 21. Single-Trial Readiness Potentials and Fatigue.- 22. The Senses of Effort and Force during Fatiguing Contractions.- 23. Tryptophan, 5-Hydroxytryptamine and a Possible Explanation for Central Fatigue.- Section VII: Task Dependency of Fatigue Mechanisms.- 24. The Significance of Motor Unit Variability in Sustaining Mechanical Output of Muscle.- 25. Intramuscular Pressures for Monitoring Different Tasks and Muscle Conditions.- 26. Task-Dependent Nature of Fatigue in Single Motor Units.- 27. Task-Dependent Factors in Fatigue of Human Voluntary Contractions.- Section VIII: Integrative Systems Issues.- 28. Fatigue and the Design of the Respiratory System.- 29. An Integrative View of Limitations to Muscular Performance.- 30. Respiratory Muscle Fatigue.- 31. Fatigue of Jaw Muscles and Speech Mechanisms.- Section IX: Fatigue of Adapted Systems: Overuse, Underuse, and Pathophysiology.- 32. Fatigue in Adapted Systems: Overuse and Underuse Paradigms.- 33. Associations between Muscle Soreness, Damage, and Fatigue.- 34. Muscle Fatigue in Old Animals: Unique Aspects of Fatigue in Elderly Humans.- 35. Historical Perspective: A Framework for Interpreting Pathobiological Ideas on Human Muscle Fatigue.- 36. Fatigue Brought on by Malfunction of the Central and Peripheral Nervous Systems.- Epilogue.- 37. Neurobiology of Muscle Fatigue: Advances and Issues.- Contributors.

Editorial Reviews

Reviewer: Konstantin V. Slavin, MD (University of Illinois at Chicago College of Medicine)
Description: The book summarizes current knowledge on muscle fatigue, its nature and mechanisms, with special emphasis on systemic integration, particularly in cardiorespiratory system. Most of the material was presented at International Symposium on Neural and Neuromuscular Aspects of Muscular Fatigue in Miami in November 1994.
Purpose: The editors put their objective in providing a systematic review of various topics on neurobiology of muscular fatigue and building a reference text in this fast developing area. In view of the growing interest to this area of neuroscience, preparation of such a summary book is certainly timely and valuable. The editors made the book complete, useful, and readable.
Audience: Although the editors direct their book to practicing healthcare professionals, teaching faculty, and biomedical trainees, the book will be more interesting to neurobiologists, neurophysiologists and other neuroscientists, and to lesser degree practicing physicians and surgeons. Authors of the book are the participants of the Miami symposium — scientists from 12 different countries of Europe, North America, and Australia.
Features: The book has many black and white illustrations, mainly graphs and schemes; it has a good set of pertinent references at the end of each chapter; and the index at the end of the book is helpful in finding necessary information. The introduction to each of the nine sections summarizes the contents of the following chapters and gives an overview of the section's subject. The book starts with a tribute to Dr. Bigland-Ritchie, one of the pioneers and most active researchers of the field. The epilogue provides an overview and future directions of the subject.
Assessment: This book is a cornerstone of the newly developing field of neuroresearch, dealing with various aspects of fatigue based on latest scientific data. This comprehensive topic review will be helpful for neuroscientists and biologists interested in studying fatigue, its basis and mechanisms. The book also deserves to be placed in any medical and biological library.

Doody's Review Service

4 Stars! from Doody

The book summarizes current knowledge on muscle fatigue, its nature and mechanisms, with special emphasis on systemic integration, particularly in cardiorespiratory system. Most of the material was presented at International Symposium on Neural and Neuromuscular Aspects of Muscular Fatigue in Miami in November 1994. The editors put their objective in providing a systematic review of various topics on neurobiology of muscular fatigue and building a reference text in this fast developing area. In view of the growing interest to this area of neuroscience, preparation of such a summary book is certainly timely and valuable. The editors made the book complete, useful, and readable. Although the editors direct their book to practicing healthcare professionals, teaching faculty, and biomedical trainees, the book will be more interesting to neurobiologists, neurophysiologists and other neuroscientists, and to lesser degree practicing physicians and surgeons. Authors of the book are the participants of the Miami symposium -- scientists from 12 different countries of Europe, North America, and Australia. The book has many black and white illustrations, mainly graphs and schemes; it has a good set of pertinent references at the end of each chapter; and the index at the end of the book is helpful in finding necessary information. The introduction to each of the nine sections summarizes the contents of the following chapters and gives an overview of the section's subject. The book starts with a tribute to Dr. Bigland-Ritchie, one of the pioneers and most active researchers of the field. The epilogue provides an overview and future directions of the subject. This book is a cornerstone of thenewly developing field of neuroresearch, dealing with various aspects of fatigue based on latest scientific data. This comprehensive topic review will be helpful for neuroscientists and biologists interested in studying fatigue, its basis and mechanisms. The book also deserves to be placed in any medical and biological library.

Konstantin V. Slavin

Based on presentations at an international symposium on Neural and Neuromuscular Aspects of Muscular Fatigue, held in Miami, Florida, November 1994, this volume describes the current state of knowledge on the neurobiology of muscle fatigue, covering processes that operate from the forebrain to the contractile proteins. Issues are addressed in nine interrelated areas: fatigue of single muscle fibers; fatigue at the neuromuscular junction; fatigue of single motor units; metabolic fatigue studied with NMR; fatigue of the segmental motor system; fatigue involving suprasegmental mechanisms; the task dependency of fatigue mechanisms; integrative (largely cardiorespiratory) systems issues; and fatigue of adapted systems (due to aging, under-and overuse, and pathophysiology). Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews