Airways Smooth Muscle: Biochemical Control of Contraction and Relaxation

by David Raeburn, Mark A. Giembycz

Overview

The study of airways smooth muscle has intensified over recent years against a background of a growing incidence of asthma and other respiratory disorders. Building on the previous volumes on the series, this research monograph focuses upon the biochemical regulation of contraction and relaxation of airways smooth muscle.

Product Details

ISBN-13:	9783034876834
Publisher:	Birkhäuser Basel
Publication date:	09/12/2012
Series:	Respiratory Pharmacology and Pharmacotherapy
Edition description:	Softcover reprint of the original 1st ed. 1994
Pages:	352
Product dimensions:	6.69(w) x 9.61(h) x 0.03(d)

Table of Contents

1. Smooth Muscle Myosin: Molecule Conformation, Filament Assembly and Associated Regulatory Enzymes.- 2. Actin and Thin-Filament-Associated Proteins in Smooth Muscle.- 3. Current Concepts on Mechanisms of Force Generation in Airways Smooth Muscle.- 4. Phosphoinositidase C, Inositol Polyphosphates and Force Generation of Airways Smooth Muscle.- 5. The Intracellular Calcium Store in Airways Smooth Muscle.- 6. Current Concepts on Mechanisms of Force Maintenance in Airways Smooth Muscle.- 7. Diglyceride, Protein Kinase C and Force Maintenance of Airways Smooth Muscle.- 8. Sources of Activator Calcium for Force Generation and Maintenance of Airways Smooth Muscle.- 9. G-Proteins in Airways Smooth Muscle.- 10. Cyclic AMP and the Control of Airways Smooth Muscle Tone.- 11. Myosin Dephosphorylation as a Mechanism of Relaxation of Airways Smooth Muscle.- 12. Cyclic GMP and the Control of Airways Smooth Muscle Tone.- 13. Cyclic Nucleotide Phosphodiesterases in Airways Smooth Muscle.- 14. Modulation of Agonist-Stimulated Phosphoinositide Turnover in Airways Smooth Muscle by Cyclic Nucleotide-Dependent and Independent Mechanisms.- 15. Airways Smooth Muscle Cells in Culture.